BIOMAT Database Logo BIOMAT Database Logo

Fatty Acids Composition and HIV Infection: Altered Levels of n-6 Polyunsaturated Fatty Acids Are Associated with Disease Progression. 2023

Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, NO-0420 Oslo, Norway.

Fatty acids (FAs) are important regulators of immune responses and innate defense mechanisms. We hypothesized that disturbed FA metabolism could contribute to the progression of HIV infection. Plasma levels of 45 FAs were analyzed with gas chromatography in healthy controls and HIV-infected patients with regard to Mycobacterium avium complex (MAC) infection. In vitro, we assessed MAC-PPD-induced release of inflammatory cytokines in peripheral and bone marrow mononuclear cells (PBMC and BMMC) according to levels of n-6 polyunsaturated fatty acids (PUFAs). While plasma saturated FAs were higher in HIV infection, PUFAs, and in particular the n-6 PUFA arachidonic acid (AA), were lower in patients with advanced disease. The ratio between AA and precursor dihomo-γ-linolenic acid, reflecting Δ5-desaturase activity, was markedly lower and inversely correlated with plasma HIV RNA levels in these patients. Depletion of AA was observed prior to MAC infection, and MAC-PPD-induced release of TNF and IL-6 in PBMC and BMMC was lower in patients with low plasma AA. Our findings suggest that dysregulated metabolism of n-6 PUFAs may play a role in the progression of HIV infection. While high AA may contribute to chronic inflammation in asymptomatic HIV-infected patients, low AA seems to increase the susceptibility to MAC infection in patients with advanced disease.

UI MeSH Term Description Entries
D007963 Leukocytes, Mononuclear Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules. Mononuclear Leukocyte,Mononuclear Leukocytes,PBMC Peripheral Blood Mononuclear Cells,Peripheral Blood Human Mononuclear Cells,Peripheral Blood Mononuclear Cell,Peripheral Blood Mononuclear Cells,Leukocyte, Mononuclear
D005227 Fatty Acids Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed) Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids
D005231 Fatty Acids, Unsaturated FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds. Fatty Acids, Polyunsaturated,Polyunsaturated Fatty Acid,Unsaturated Fatty Acid,Polyunsaturated Fatty Acids,Acid, Polyunsaturated Fatty,Acid, Unsaturated Fatty,Acids, Polyunsaturated Fatty,Acids, Unsaturated Fatty,Fatty Acid, Polyunsaturated,Fatty Acid, Unsaturated,Unsaturated Fatty Acids
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015658 HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS). HTLV-III Infections,HTLV-III-LAV Infections,T-Lymphotropic Virus Type III Infections, Human,HIV Coinfection,Coinfection, HIV,Coinfections, HIV,HIV Coinfections,HIV Infection,HTLV III Infections,HTLV III LAV Infections,HTLV-III Infection,HTLV-III-LAV Infection,Infection, HIV,Infection, HTLV-III,Infection, HTLV-III-LAV,Infections, HIV,Infections, HTLV-III,Infections, HTLV-III-LAV,T Lymphotropic Virus Type III Infections, Human
D016718 Arachidonic Acid An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. (all-Z)-5,8,11,14-Eicosatetraenoic acid,Arachidonic Acid, (all-Z)-Isomer, 1-(14)C-Labeled,Arachidonic Acid, (all-Z)-isomer, 3H-Labeled,Arachidonic Acid, Ammonium Salt, (all-Z)-Isomer,Arachidonic Acid, Cerium Salt, (all-Z)-Isomer,Arachidonic Acid, Cesium Salt, (all-Z)-Isomer,Arachidonic Acid, Lithium Salt, (all-Z)-Isomer,Arachidonic Acid, Potassium Salt, (all-Z)-Isomer,Arachidonic Acid, Sodium Salt,Arachidonic Acid, Sodium Salt, (all-Z)-Isomer,Arachidonic Acid, Zinc Salt, (all-Z)-Isomer,Sodium Arachidonate,Vitamin F,Arachidonate, Sodium
D043371 Fatty Acids, Omega-6 FATTY ACIDS which have the first unsaturated bond in the sixth position from the omega carbon. A typical American diet tends to contain substantially more omega-6 than OMEGA-3 FATTY ACIDS. N-6 Fatty Acid,Omega-6 Fatty Acid,Omega-6 Fatty Acids,Fatty Acids, Omega 6,N-6 Fatty Acids,Acid, N-6 Fatty,Acid, Omega-6 Fatty,Acids, N-6 Fatty,Acids, Omega-6 Fatty,Fatty Acid, N-6,Fatty Acid, Omega-6,Fatty Acids, N-6,N 6 Fatty Acid,N 6 Fatty Acids,Omega 6 Fatty Acid,Omega 6 Fatty Acids
D018450 Disease Progression The worsening and general progression of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis. Clinical Course,Clinical Progression,Disease Exacerbation,Exacerbation, Disease,Progression, Clinical,Progression, Disease

Related Publications

Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Dietary n-3 and n-6 fatty acids: are there 'bad' polyunsaturated fatty acids?
March 2010, Current opinion in clinical nutrition and metabolic care,
Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Altered hepatic gene expression in nonalcoholic fatty liver disease is associated with lower hepatic n-3 and n-6 polyunsaturated fatty acids.
May 2015, Hepatology (Baltimore, Md.),
Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Polyunsaturated fatty acids (n-3, n-6).
May 1987, The American journal of clinical nutrition,
Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Plasma n-3 Polyunsaturated Fatty Acids are negatively associated with obesity.
November 2009, The British journal of nutrition,
Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Non-alcoholic fatty liver disease in HIV infection associated with altered hepatic fatty acid composition.
March 2011, Current HIV research,
Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
n-6 Polyunsaturated fatty acids and breast cancer.
January 2003, Nutrition and cancer,
Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Dietary n-6 polyunsaturated fatty acids and cardiovascular disease: Epidemiologic evidence.
August 2018, Prostaglandins, leukotrienes, and essential fatty acids,
Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Unique fatty acid composition of normal cartilage: discovery of high levels of n-9 eicosatrienoic acid and low levels of n-6 polyunsaturated fatty acids.
March 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.
January 2018, Journal of clinical lipidology,
Thor Ueland, and Bjørn Waagsbø, and Rolf K Berge, and Marius Trøseid, and Pål Aukrust, and Jan K Damås
Exploration of n-6 and n-3 Polyunsaturated Fatty Acids Metabolites Associated with Nutritional Levels in Patients with Severe Stable Chronic Obstructive Pulmonary Disease.
January 2020, International journal of chronic obstructive pulmonary disease,
Copied contents to your clipboard!