Biomaterial Database

HIV-Associated Progressive Multifocal Leukoencephalopathy: A Case Study. 2023

Elsayed Abed, and Ahmed Farag El-Adawey, and Mohamed Hamed Rashad, and Ahmed Essmat, and Mohammed Ali, and Ahmed Hassan Elsheshiny, and Abdel-Ghaffar Fayed, and Fathy Elbaz, and Mahmoud Galal Ahmed, and Zohreh Abna, and Shaimaa Sayed Khater

Department of Neurology, Faculty of Medicine, Al-Azhar University, Cairo, 11651, Egypt. ElsayedAbed.226@azhar.edu.eg.

Progressive multifocal leukoencephalopathy (PML) is a rare, life-threatening, infectious, lytic, demyelinating disease that results from reactivation of the virulent JC polyomavirus (JCV) "major opportunistic infection" in immunosuppressed individuals. We reported a case of a young girl who presented with new onset focal neurological defect, evaluated, and laboratory and radiological findings in the context of a clinical setting confirmed HIV-related-PML infection. However, remyelination does not occur, the patients may develop complications in the long term including cognitive impairment, sensory deficits, motor deficits, and disturbances in balance. We must increase our knowledge about HIV- related PML in any patient with reduced immunity and who presented with new onset neurological defect.