GCKR and ADIPOQ gene polymorphisms in women with gestational diabetes mellitus. 2023

Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

OBJECTIVE To investigate the associations of GCKR and ADIPOQ variants with the risk of gestational diabetes mellitus (GDM) in Chinese women. METHODS GCKR rs1260326, ADIPOQ rs266729, and rs1501299 were selected and genotyped in 519 GDM patients and 498 controls. Candidate SNPs were genotyped using multiplex polymerase chain reaction (PCR) combined with next-generation sequencing methods, and the association of these SNPs with GDM was analyzed. RESULTS We found that GCKR rs1260326 was significantly associated with an increased risk of GDM in the allele model, the codominant model (CC vs. TT), the dominant model, the recessive model, and the genotypic model distributions (p = 0.0029, p = 0.0022, p = 0.0402, p = 0.0038, and p = 0.0028, respectively). The rs1260326 polymorphism was shown to be associated with 1 h-OGTT level and gravidity in GDM patients (CC vs. TT: p = 0.0475 and p = 0.0220, respectively). Diastolic blood pressure (DBP) was significantly higher in the GDM patients with the rs266729 GG genotype compared to those with the CC or CG genotype (p = 0.0444 and p = 0.0339, respectively). The DBP of the GDM patients with the rs1501299 GT genotype was lower than that of those with the GG genotype (p = 0.0197). There was a weak linkage disequilibrium value between the GCKR and ADIPOQ SNPs. CONCLUSIONS The genes GCKR and ADIPOQ may be involved in the pathophysiology of GDM.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000483 Alleles Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product. Allelomorphs,Allele,Allelomorph
D016022 Case-Control Studies Comparisons that start with the identification of persons with the disease or outcome of interest and a control (comparison, referent) group without the disease or outcome of interest. The relationship of an attribute is examined by comparing both groups with regard to the frequency or levels of outcome over time. Case-Base Studies,Case-Comparison Studies,Case-Referent Studies,Matched Case-Control Studies,Nested Case-Control Studies,Case Control Studies,Case-Compeer Studies,Case-Referrent Studies,Case Base Studies,Case Comparison Studies,Case Control Study,Case Referent Studies,Case Referrent Studies,Case-Comparison Study,Case-Control Studies, Matched,Case-Control Studies, Nested,Case-Control Study,Case-Control Study, Matched,Case-Control Study, Nested,Case-Referent Study,Case-Referrent Study,Matched Case Control Studies,Matched Case-Control Study,Nested Case Control Studies,Nested Case-Control Study,Studies, Case Control,Studies, Case-Base,Studies, Case-Comparison,Studies, Case-Compeer,Studies, Case-Control,Studies, Case-Referent,Studies, Case-Referrent,Studies, Matched Case-Control,Studies, Nested Case-Control,Study, Case Control,Study, Case-Comparison,Study, Case-Control,Study, Case-Referent,Study, Case-Referrent,Study, Matched Case-Control,Study, Nested Case-Control
D016640 Diabetes, Gestational Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA. Diabetes Mellitus, Gestational,Diabetes, Pregnancy-Induced,Gestational Diabetes,Diabetes, Pregnancy Induced,Gestational Diabetes Mellitus,Pregnancy-Induced Diabetes
D048868 Adaptor Proteins, Signal Transducing A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes Signal Transducing Adaptor Proteins
D052242 Adiponectin A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS. ACRP30 Protein,Adipocyte Complement-Related Protein 30-kDa,Adipocyte, C1q and Collagen Domain Containing Protein,Adipose Most Abundant Gene Transcript 1,apM-1 Protein,Adipocyte Complement Related Protein 30 kDa,apM 1 Protein
D020022 Genetic Predisposition to Disease A latent susceptibility to disease at the genetic level, which may be activated under certain conditions. Genetic Predisposition,Genetic Susceptibility,Predisposition, Genetic,Susceptibility, Genetic,Genetic Predispositions,Genetic Susceptibilities,Predispositions, Genetic,Susceptibilities, Genetic

Related Publications

Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
August 2017, Canadian journal of diabetes,
Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
January 2021, Diabetes, metabolic syndrome and obesity : targets and therapy,
Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
April 2017, Journal of assisted reproduction and genetics,
Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
November 2023, BMC endocrine disorders,
Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
January 2017, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
October 2018, Archives of gynecology and obstetrics,
Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
July 2022, Genes,
Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
March 2019, Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,
Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
April 2023, Biomedicines,
Manning Zhu, and Yaer Lv, and Yanqing Peng, and Yingnan Wu, and Yanan Feng, and Tianshuang Jia, and Songcheng Xu, and Songxue Li, and Wei Wang, and Jiawei Tian, and Litao Sun
October 2018, Endocrine,
Copied contents to your clipboard!