BDNF CpG methylation and serum levels covary during alcohol withdrawal in patients with alcohol use disorder: A pilot study. 2023

Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
Unité de Recherche et d'Innovation, Fédération de la recherche et de l'innovation, Centre Hospitalier Esquirol, Limoges, France.

Brain-derived neurotrophic factor (BDNF) levels vary in various conditions including alcohol use disorder (AUD). We aimed to identify drivers of these variations. Twelve patients with AUD were assessed at hospitalisation for alcohol withdrawal and four months later. We looked for associations between the change in serum BDNF levels and (1) length of abstinence, (2) anxiety (Hamilton Anxiety Scale) and depression (Beck-Depression Inventory), (3) one functional BDNF genotype (rs6265) and (4) methylation levels of 12 CpG sites within the BDNF gene (located in exons I, IV and IX). While abstinence remained, serum BDNF level increased. This increase correlated with the variation of methylation levels of the BDNF gene, and more specifically of exon I. We found no significant effect of length of abstinence, rs6265, depression or anxiety on serum BDNF level. Epigenetic regulation of the BDNF gene may be involved in variations of BDNF blood level associated with alcohol abstinence.

UI MeSH Term Description Entries
D010865 Pilot Projects Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work. Pilot Studies,Pilot Study,Pilot Project,Project, Pilot,Projects, Pilot,Studies, Pilot,Study, Pilot
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000437 Alcoholism A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4) Alcohol Abuse,Alcoholic Intoxication, Chronic,Ethanol Abuse,Alcohol Addiction,Alcohol Dependence,Alcohol Use Disorder,Abuse, Alcohol,Abuse, Ethanol,Addiction, Alcohol,Alcohol Use Disorders,Chronic Alcoholic Intoxication,Dependence, Alcohol,Intoxication, Chronic Alcoholic,Use Disorders, Alcohol
D013375 Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug. Drug Withdrawal Symptoms,Withdrawal Symptoms,Drug Withdrawal Symptom,Substance Withdrawal Syndromes,Symptom, Drug Withdrawal,Symptom, Withdrawal,Symptoms, Drug Withdrawal,Symptoms, Withdrawal,Syndrome, Substance Withdrawal,Syndromes, Substance Withdrawal,Withdrawal Symptom,Withdrawal Symptom, Drug,Withdrawal Symptoms, Drug,Withdrawal Syndrome, Substance,Withdrawal Syndromes, Substance
D044127 Epigenesis, Genetic A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression. Epigenetic Processes,Epigenetic Process,Epigenetics Processes,Genetic Epigenesis,Process, Epigenetic,Processes, Epigenetic,Processes, Epigenetics
D019175 DNA Methylation Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor. DNA Methylations,Methylation, DNA,Methylations, DNA
D019208 Brain-Derived Neurotrophic Factor A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994) BDNF,Brain Derived Neurotrophic Factor,Factor, Brain-Derived Neurotrophic,Neurotrophic Factor, Brain-Derived

Related Publications

Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
August 2010, Progress in neuro-psychopharmacology & biological psychiatry,
Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
March 2021, The American journal of drug and alcohol abuse,
Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
August 2016, Alcohol (Fayetteville, N.Y.),
Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
September 2023, Alcohol (Fayetteville, N.Y.),
Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
December 2020, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry,
Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
August 2018, Neuroscience letters,
Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
April 2009, Journal of gastroenterology and hepatology,
Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
January 2024, Journal of psychoactive drugs,
Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
June 2022, EBioMedicine,
Aurélie Lacroix, and Nicolas Ramoz, and Murielle Girard, and Brigitte Plansont, and Daphnée Poupon, and Philip Gorwood, and Philippe Nubukpo
January 2012, European addiction research,
Copied contents to your clipboard!