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Clorsulon (3.5 or 7 mg/kg of body weight) was given orally to mature cows (dairy or beef) and to mature mixed-breed sheep harboring patent infections of Fasciola hepatica. Eighteen animals of each species were assigned to a control group (drug vehicle) or to 1 of 2 treatment (3.5 or 7.0 mg/kg) groups of 6 animals each. On posttreatment days 8 (cows) or 14 (sheep), the animals were slaughtered for recovery of flukes. In cows, the efficacy (P values for treatment groups vs control) of clorsulon against infections of mature F hepatica was 99.21% (P less than or equal to 0.0065) at 3.5 mg/kg and was 100% (P less than or equal to 0.0039) at 7 mg/kg. In sheep, the efficacy was 93.33% (P less than or equal to 0.0104) at 3.5 mg/kg and was 100% (P less than or equal to 0.0039) at 7 mg/kg. These results indicate that clorsulon is a highly effective compound for the treatment of mature F hepatica in cows and sheep.
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
May 1984,
American journal of veterinary research,
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
June 1985,
Veterinary parasitology,
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
July 1985,
American journal of veterinary research,
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
October 1999,
The Veterinary record,
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
January 1988,
The Veterinary record,
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
August 1971,
American journal of veterinary research,
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
June 1981,
American journal of veterinary research,
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
October 2006,
Parasitology research,
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
April 2007,
Parasitology research,
G L Zimmerman, and
D H Wallace, and
D J Schons, and
E P Hoberg
January 1985,
American journal of veterinary research,
