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Mycophenolic acid (MPA) was demonstrated to inhibit DNA and RNA synthesis in L1210 cells strongly; however these effects were remarkably reduced by guanine. The presence of MPA in the medium decreased the guanine nucleotide contents (GMP, GDP, GTP) of the cells, but the addition of guanine reversed this effect. We have reported previously that MPA had no inhibitory effect on hypoxanthine guanine phosphoribosyltransferase (HGPRTase) activity. Together these findings suggest that the decrease of guanine nucleotides induced by MPA is restored by GMP, which is formed from guanine by HGPRTase in the cells. It is speculated that a suppressor of HGPRTase activity, such as 6-mercaptopurine, may protect the antitumor activity of MPA by preventing the conversion of guanine to GMP.
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
July 1969,
The Biochemical journal,
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
March 1977,
Cancer research,
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
February 1994,
Toxicology letters,
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
January 2005,
FEBS letters,
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
January 1972,
Clinical pharmacology and therapeutics,
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
July 1991,
Cytotechnology,
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
February 1968,
Biochemical pharmacology,
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
January 1970,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. 1. Abt. Medizinisch-hygienische Bakteriologie, Virusforschung und Parasitologie. Originale,
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
July 2014,
Biopharmaceutics & drug disposition,
D Kagawa, and
T Nakamura, and
T Ueda, and
S Ando, and
H Tsutani, and
M Uchida, and
N Domae, and
M Sasada, and
H Uchino
January 1969,
Revue francaise d'etudes cliniques et biologiques,
