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AD6 is a coumarinic derivative which increases both coronary blood flow and prostacyclin production, while it decreases platelet responsiveness. We tested its action on experimental cardiac arrhythmias. AD6 (2.5-10 mg/kg) was able to antagonize the arrhythmogenic action of aconitine in rats and of adrenaline in cats. AD6 action was also tested in vitro. The drug (20-50 microM) prolonged the functional refractory period of guinea-pig atrial and ventricular muscle and lengthened the refractory period shortened by hypoxia. Intracellular electrophysiological experiments showed that AD6 prolongs action potential duration (APD) of guinea-pig atrial myocardium, sino-atrial node and cat Purkinje fibers. The results obtained in vitro may explain the effect on experimental arrhythmias, therefore suggesting a protective action on cardiac rhythm disturbances.
M Bertolino, and
M Prosdocimi, and
F Aporti, and
M Finesso, and
A Gorio
January 1971,
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M Bertolino, and
M Prosdocimi, and
F Aporti, and
M Finesso, and
A Gorio
January 1989,
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M Bertolino, and
M Prosdocimi, and
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A Gorio
February 1969,
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M Bertolino, and
M Prosdocimi, and
F Aporti, and
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February 1950,
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M Bertolino, and
M Prosdocimi, and
F Aporti, and
M Finesso, and
A Gorio
February 1980,
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M Bertolino, and
M Prosdocimi, and
F Aporti, and
M Finesso, and
A Gorio
October 1977,
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M Bertolino, and
M Prosdocimi, and
F Aporti, and
M Finesso, and
A Gorio
January 1979,
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M Bertolino, and
M Prosdocimi, and
F Aporti, and
M Finesso, and
A Gorio
November 1977,
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M Bertolino, and
M Prosdocimi, and
F Aporti, and
M Finesso, and
A Gorio
February 1951,
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M Bertolino, and
M Prosdocimi, and
F Aporti, and
M Finesso, and
A Gorio
January 1955,
Archives internationales de pharmacodynamie et de therapie,
