-transparent.png){kind=logo}
Serum IgG and IgA antibodies to wheat germ agglutinin (WGA) were measured by an enzyme-linked immunosorbent assay (ELISA) with N-acetyl-D-glucosamine in all incubation steps to inhibit sugar-specific binding. Patients with coeliac disease (CD) had significantly higher antibody levels to WGA than patients with other intestinal disorders or healthy controls. Similar results were obtained for antibodies to the gluten fraction glyc-gli. The WGA antibodies did apparently not cross-react with gluten antigens, but commercial gluten powder contained traces of WGA or a similar lectin. Our findings support the proposal that WGA may be involved in the pathogenesis of CD.
Related Publications
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
June 1974,
Archives of disease in childhood,
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
March 1982,
The Journal of cell biology,
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
April 1987,
Plant cell reports,
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
January 1987,
Journal of electron microscopy,
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
May 1982,
European journal of biochemistry,
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
November 1980,
Plant physiology,
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
July 1974,
Biochemical and biophysical research communications,
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
January 1973,
Nature,
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
April 1972,
The Journal of biological chemistry,
L M Sollid, and
J Kolberg, and
H Scott, and
J Ek, and
O Fausa, and
P Brandtzaeg
July 1979,
European journal of biochemistry,
