BIOMAT Database Logo BIOMAT Database Logo

Next generation anticoagulants: a spotlight on the potential role of activated factors XII and XI. 2023

Helen Philippou, and Evi X Stavrou
Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds, West Yorkshire, UK.

UI MeSH Term Description Entries
D001777 Blood Coagulation The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot. Blood Clotting,Coagulation, Blood,Blood Clottings,Clotting, Blood
D005172 Factor XI Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C. Coagulation Factor XI,Plasma Thromboplastin Antecedent,Blood Coagulation Factor XI,Factor 11,Factor Eleven,Antecedent, Plasma Thromboplastin,Factor XI, Coagulation,Thromboplastin Antecedent, Plasma
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000925 Anticoagulants Agents that prevent BLOOD CLOTTING. Anticoagulant Agent,Anticoagulant Drug,Anticoagulant,Anticoagulant Agents,Anticoagulant Drugs,Anticoagulation Agents,Indirect Thrombin Inhibitors,Agent, Anticoagulant,Agents, Anticoagulant,Agents, Anticoagulation,Drug, Anticoagulant,Drugs, Anticoagulant,Inhibitors, Indirect Thrombin,Thrombin Inhibitors, Indirect
D015956 Factor XIIa Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII. Coagulation Factor XIIa,Factor XII, Activated,Activated Factor XII,Blood Coagulation Factor XII, Activated,Factor 12A,Factor Twelve A,Hageman-Factor Fragments,Prekallikrein Activator,Activator, Prekallikrein,Factor XIIa, Coagulation,Fragments, Hageman-Factor,Hageman Factor Fragments

Related Publications

Helen Philippou, and Evi X Stavrou
Factors XI and XII as Targets for New Anticoagulants.
January 2017, Frontiers in medicine,
Helen Philippou, and Evi X Stavrou
Generation of coagulation factors V, XI, and XII by the isolated rat liver.
January 1977, Haemostasis,
Helen Philippou, and Evi X Stavrou
Factor XI and factor XII as targets for new anticoagulants.
May 2016, Thrombosis research,
Helen Philippou, and Evi X Stavrou
Activation of factors XII and XI in thrombogenesis.
February 1972, Bulletin of the New York Academy of Medicine,
Helen Philippou, and Evi X Stavrou
[Proceedings: Congenital deficiency of factors XI and XII].
December 1973, Minerva pediatrica,
Helen Philippou, and Evi X Stavrou
ROLE OF FACTORS XII, XI, AND IX IN SERUM AND PLASMA-INDUCED THROMBOSIS.
December 1963, The American journal of physiology,
Helen Philippou, and Evi X Stavrou
Factors IX, XI, and XII: potential therapeutic targets for anticoagulant therapy in atherothrombosis.
December 2019, Reviews in cardiovascular medicine,
Helen Philippou, and Evi X Stavrou
[Determination of prothromboplastin factors (Factors VIII, IX, XI and XII)].
January 1976, Nihon rinsho. Japanese journal of clinical medicine,
Helen Philippou, and Evi X Stavrou
Thrombin activates factor XI on activated platelets in the absence of factor XII.
January 1999, Arteriosclerosis, thrombosis, and vascular biology,
Helen Philippou, and Evi X Stavrou
The relation of 'Fletcher Factor' to factors XI and XII.
February 1970, British journal of haematology,
Copied contents to your clipboard!