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To determine the role of platelet-activating factor (PAF) in endotoxin shock, we studied the effects of ONO-6240, a PAF antagonist, on endotoxin shock in unanesthetized sheep. Changes in hemodynamics, lung lymph balance, leukocyte and platelet counts, and arterial blood gas tensions were measured in four groups; endotoxin alone; endotoxin plus ONO-6240; ONO-6240 alone; vehicle control. Pretreatment with ONO-6240 in sheep given endotoxin significantly prevented the decreases in systemic arterial pressure, left atrial pressure and cardiac output observed in sheep given endotoxin alone. A partial effect on diminishing the magnitude of peripheral leukopenia was also noted. However, pretreatment with ONO-6240 had little effect on pulmonary hypertension and lung lymph balance. We conclude that endotoxin causes two different effects: vascular collapse and direct lung injury; and that PAF is involved only in the circulatory manifestations.
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
June 1990,
Asia-Oceania journal of obstetrics and gynaecology,
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
November 1995,
Zhonghua nei ke za zhi,
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
October 1994,
Shock (Augusta, Ga.),
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
March 1987,
European journal of pharmacology,
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
December 1988,
Journal of applied physiology (Bethesda, Md. : 1985),
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
September 1992,
Circulatory shock,
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
April 1995,
The Journal of veterinary medical science,
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
February 1985,
European journal of pharmacology,
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
August 1995,
The Journal of veterinary medical science,
T Toyofuku, and
K Kubo, and
T Kobayashi, and
S Kusama
July 1991,
The Journal of trauma,
