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Morphine (200 micrograms/rat) was injected intraventricularly (i.v.t.) into normal and into long-term castrated (4 weeks) adult male rats. Animals were killed 10, 20, 40 and 60 min after treatment. In normal animals, the treatment with morphine resulted in a significant increase of serum prolactin concentrations at all time intervals considered. However, the i.v.t. injection of 200 micrograms morphine/rat into castrated rats did not exert any significant effect on prolactin release at any time interval considered. When morphine (200 micrograms/rat) was administered i.v.t. together with the specific opioid receptor blocker naloxone (7.5 or 15 micrograms/rat) the stimulatory effect of morphine on prolactin release was diminished at 10 min, and totally blocked at 20 min. Naloxone given alone did not influence serum prolactin concentrations. The results suggest that the presence of endogenous androgens is essential to permit the stimulatory effect of morphine on prolactin release.
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
March 1985,
Pharmacology, biochemistry, and behavior,
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
June 1993,
Neuroendocrinology,
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
January 1996,
Pharmacological research,
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
November 1982,
Endocrinology,
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
March 1990,
Brain research,
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
October 1998,
Brain research,
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
August 2010,
Neuropeptides,
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
January 1979,
Neuroendocrinology,
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
June 1981,
Behavioral and neural biology,
P Limonta, and
F Piva, and
R Maggi, and
D Dondi, and
M Motta, and
L Martini
October 1989,
Endocrinology,
