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Thrombi were electrically induced in dogs. The alterations of the vessel wall were studied in samples obtained on the 8th day from control and treated animals. Changes in coagulation parameters were monitored daily. Animals were treated with 600 mg defibrotide (Crinos) daily for a week, starting 24 h after the induction of thrombi. In the control dogs there was thickening of intima with endothelial hyperplasia and smooth muscle proliferation. The treated animals did not show any morphological or ultrastructural alterations (SEM). This observation encourages us to examine the role of fibrinolytic and endothelial supportive therapy for prevention of development of vascular changes.
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H Tunali, and
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S Aytiş, and
T Erbengi, and
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January 1978,
Basic research in cardiology,
O N Ulutin, and
H Tunali, and
M S Uğur, and
S Aytiş, and
T Erbengi, and
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June 1965,
Journal of neurosurgery,
O N Ulutin, and
H Tunali, and
M S Uğur, and
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T Erbengi, and
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October 1982,
Zeitschrift fur experimentelle Chirurgie,
O N Ulutin, and
H Tunali, and
M S Uğur, and
S Aytiş, and
T Erbengi, and
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January 1977,
Zeitschrift fur experimentelle Chirurgie,
O N Ulutin, and
H Tunali, and
M S Uğur, and
S Aytiş, and
T Erbengi, and
S Balkuv-Ulutin
October 1982,
Zeitschrift fur experimentelle Chirurgie,
O N Ulutin, and
H Tunali, and
M S Uğur, and
S Aytiş, and
T Erbengi, and
S Balkuv-Ulutin
January 1987,
Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR,
O N Ulutin, and
H Tunali, and
M S Uğur, and
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T Erbengi, and
S Balkuv-Ulutin
June 1978,
American journal of veterinary research,
O N Ulutin, and
H Tunali, and
M S Uğur, and
S Aytiş, and
T Erbengi, and
S Balkuv-Ulutin
January 1980,
The Journal of physiology,
O N Ulutin, and
H Tunali, and
M S Uğur, and
S Aytiş, and
T Erbengi, and
S Balkuv-Ulutin
October 1987,
Thrombosis research,
O N Ulutin, and
H Tunali, and
M S Uğur, and
S Aytiş, and
T Erbengi, and
S Balkuv-Ulutin
January 1987,
Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR,
