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A group of 35,000-dalton sialoglycoproteins is the major non-serum protein component of pulmonary surfactant. Tryptic fragments of these proteins were sequenced, and oligonucleotide probes were synthesized based on the amino acid sequences. A human lung cDNA library was then screened using the oligonucleotide probes, and clones coding for these proteins were identified and characterized. By in vitro transcription-translation experiments we have associated individual clones with particular proteins. The data suggest that co-translational modifications of two primary translation products account for many of the isoforms observed by two-dimensional gel electrophoresis in the precursors of 35,000-dalton sialoglycoproteins.
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
July 1985,
Proceedings of the National Academy of Sciences of the United States of America,
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
April 1989,
Biochemical and biophysical research communications,
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
January 1991,
Experimental lung research,
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
April 1987,
Biochemical and biophysical research communications,
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
September 1991,
The EMBO journal,
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
June 1991,
The Journal of biological chemistry,
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
August 1987,
Biochimica et biophysica acta,
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
October 1988,
Proceedings of the National Academy of Sciences of the United States of America,
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
April 1984,
The Journal of biological chemistry,
J Floros, and
R Steinbrink, and
K Jacobs, and
D Phelps, and
R Kriz, and
M Recny, and
L Sultzman, and
S Jones, and
H W Taeusch, and
H A Frank
September 1992,
Journal of immunology (Baltimore, Md. : 1950),
