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It has recently been postulated that thromboxane A2 may participate in the pathogenesis of acute myohemoglobinuric experimental acute renal failure. To investigate this further, the effect of selective inhibition of thromboxane synthesis on the course of glycerol-induced acute renal failure was determined. Despite significant inhibition of thromboxane synthesis by 4-imidazole-yl-acetophenone, the functional and morphologic disturbance induced by glycerol was unaltered. Moreover, pretreatment with 4-imidazole-yl-acetophenone failed to prevent the fall in renal blood flow seen following glycerol administration. These results argue against a major role for thromboxane A2 in the pathogenesis of this form of experimental acute renal failure.
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
January 1986,
Prostaglandins, leukotrienes, and medicine,
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
January 1980,
Advances in prostaglandin and thromboxane research,
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
January 1988,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
January 1989,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
March 1980,
Prostaglandins,
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
October 1980,
Kidney international,
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
July 1976,
The Journal of laboratory and clinical medicine,
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
June 1985,
The American journal of physiology,
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
January 1993,
Journal of basic and clinical physiology and pharmacology,
A J Watson, and
R L Stout, and
N F Adkinson, and
K Solez, and
A Whelton
September 1993,
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine,
