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Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques. 2023
Venkata S Bollimpelli, and
Pradeep B J Reddy, and
Sailaja Gangadhara, and
Tysheena P Charles, and
Samantha L Burton, and
Gregory K Tharp, and
Tiffany M Styles, and
Celia C Labranche, and
Justin C Smith, and
Amit A Upadhyay, and
Anusmita Sahoo, and
Traci Legere, and
Ayalnesh Shiferaw, and
Vijayakumar Velu, and
Tianwei Yu, and
Mark Tomai, and
John Vasilakos, and
Sudhir P Kasturi, and
George M Shaw, and
David Montefiori, and
Steven E Bosinger, and
Pamela A Kozlowski, and
Bali Pulendran, and
Cynthia A Derdeyn, and
Eric Hunter, and
Rama R Amara
Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia Ankara (MVA) vaccinations provide protection from acquisition of intravaginal tier2 simian-human immunodeficiency virus (SHIV) challenges in female macaques. Both routes of vaccination induce comparable levels of serum IgG with neutralizing and non-neutralizing activities. The protection in MVA-ID group correlates positively with serum neutralizing and antibody-dependent phagocytic activities, and envelope-specific vaginal IgA; while the limited protection in MVA-IM group correlates only with serum neutralizing activity. MVA-ID immunizations induce greater germinal center Tfh and B cell responses, reduced the ratio of Th1 to Tfh cells in blood and showed lower activation of intermediate monocytes and inflammasome compared to MVA-IM immunizations. This lower innate activation correlates negatively with induction of Tfh responses. These data demonstrate that the MVA-ID vaccinations protect against intravaginal SHIV challenges by modulating the innate and T helper responses.
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Celia C Labranche, and
Justin C Smith, and
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Vijayakumar Velu, and
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