Most commercial drones utilize a traditional proportional-integral-derivative (PID) controller because of its design simplicity. However, the traditional PID controller has certain limitations in terms of optimality and robustness; it is difficult to actively adjust the PID gains under some disturbances. In this study, we demonstrated an analog-digital hybrid computing platform based on double-gate SnS2 memtransistors to implement a self-tuning/energy-efficient PID controller in drones. The customized analog circuit with memtransistors executes the PID control algorithm with low power consumption; we experimentally verified that the energy consumption of the proposed hybrid computing-based PID controller is only 63% of that of the traditional PID controller. In addition, the precise tunability of analog conductance states in the memtransistor proved to be capable of reconfiguring the performance of the PID controller, where the developed self-tuning algorithm can automatically find the optimal PID control performance.