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We have found that Neuropeptide Y is colocalized with enkephalin in bovine adrenal chromaffin cells. The two peptides can be found in the same granules in those cells where they coexist. These cells correspond to the adrenergic subpopulation of chromaffin cells since they contain the epinephrine synthetic enzyme, phenylethanolamine N-methyltransferase. Despite their coexistence, production of the two peptides is independently regulated. Enkephalin levels are doubled after nicotinic depolarization (which increases enkephalin synthesis) or after treatment with reserpine (which increases enkephalin precursor processing). Neither of these treatments, acting by different mechanisms, has any effect on the levels of Neuropeptide Y.
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
May 1986,
Neuroscience,
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
January 2011,
PloS one,
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
February 1981,
Life sciences,
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
June 2000,
Life sciences,
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
March 2001,
Peptides,
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
August 1983,
Proceedings of the National Academy of Sciences of the United States of America,
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
February 1988,
The Journal of pharmacology and experimental therapeutics,
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
January 1996,
Regulatory peptides,
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
December 1985,
Neuropeptides,
R M Pruss, and
E Mezey, and
D S Forman, and
L E Eiden, and
A J Hotchkiss, and
D A DiMaggio, and
T L O'Donohue
July 1991,
Neuroendocrinology,
