-transparent.png){kind=logo}
Delta sleep-inducing peptide has been shown to exert extra-sleep effects as well as effects on sleep. In this study, the concentrations of DSIP-like immunoreactivity were measured by radioimmunoassay in the plasma of spontaneously hypertensive rats (SHR). They were found to be about 25% higher in SHR plasma than in the plasma of the normotensive Wistar-Kyoto (WK) controls. DSIP was then infused for 10 days by osmotic minipump (200 micrograms/kg/day) into SHR. This resulted in in maintenance of BP at a level of about 200 mm Hg as compared with the significant increase to about 220 mm Hg after 10 days in the SHR controls infused with 0.9% NaCl. After daily SC injection of a single dose of 200 micrograms/kg DSIP for each of 5 days in SHR, findings were similar. The results raise the possibility of an involvement of DSIP in the regulation of BP in SHR.
M V Graf, and
A J Kastin, and
G A Schoenenberger
July 2001,
European journal of anaesthesiology,
M V Graf, and
A J Kastin, and
G A Schoenenberger
July 1979,
Neuroscience letters,
M V Graf, and
A J Kastin, and
G A Schoenenberger
January 1998,
Neuroscience and behavioral physiology,
M V Graf, and
A J Kastin, and
G A Schoenenberger
September 1983,
Neuroscience letters,
M V Graf, and
A J Kastin, and
G A Schoenenberger
May 1997,
The American journal of psychiatry,
M V Graf, and
A J Kastin, and
G A Schoenenberger
June 1981,
Lancet (London, England),
M V Graf, and
A J Kastin, and
G A Schoenenberger
January 1991,
Peptides,
M V Graf, and
A J Kastin, and
G A Schoenenberger
February 1988,
International journal of peptide and protein research,
M V Graf, and
A J Kastin, and
G A Schoenenberger
August 2021,
Molecules (Basel, Switzerland),
M V Graf, and
A J Kastin, and
G A Schoenenberger
January 1998,
Neuroscience and behavioral physiology,
