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The behavioral effects of intracerebroventricularly administered neurotensin (NT), some NT fragments and two synthetic NT analogs were investigated in the open field. Each peptide was studied in both a 'novel' (no pre-exposure) and a 'familiar' (with pre-exposure) environmental situation. Neurotensin decreases locomotor activity in the periphery but increases the time spent in the central area of the apparatus. Of the congeners tested, D-Phe11-NT has similar effects to NT whereas the NT fragments were generally inactive. These findings indicate that the intact peptide or stable substituted NT analogs, but not small C- and N-terminal fragments of NT, are behaviorally active after intraventricular administration.
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
September 1984,
British journal of pharmacology,
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
February 1978,
Neuropharmacology,
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
January 1982,
Annals of the New York Academy of Sciences,
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
December 1985,
Neuropeptides,
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
January 1984,
Peptides,
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
January 1991,
Physiology & behavior,
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
March 1995,
Physiology & behavior,
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
January 2016,
ChemMedChem,
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
November 1977,
Journal of medicinal chemistry,
P J Elliott, and
J Chan, and
Y M Parker, and
C B Nemeroff
January 1993,
Brain research bulletin,
