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The effects of free and conjugated daunorubicin on T.b. rhodesiense in vitro are described. Free drug caused nucleolar lesions ranging from segregation to complete fragmentation. At equimolar concentrations a soluble bovine serum albumin conjugate with a stable succinyl linkage (D-BSAS) produced no ultrastructural lesions whereas a conjugate with a labile glutaraldehyde linkage (D-BSAG) and a conjugate linked to large agarose beads (D-ag) produced similar though less severe lesions than free drug. Polyisobutylcyanoacrylate nanoparticles caused trypanosomal lysis both with (D-PICA) and without adsorbed daunorubicin.
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