-transparent.png){kind=logo}
The effect of food on the bioavailability of 6-mercaptopurine (6-MP) has been investigated. Seven patients were studied on two separate occasions. On the first occasion 6-MP was administered p.o. after an overnight fast and on the second, 15 min after a standard breakfast. 6-MP concentrations were determined by high-performance liquid chromatography. Variable plasma drug levels were observed between individual subjects in the fasting state. The peak levels of 6-MP were lower and took longer to be achieved following administration after a standard breakfast than after an overnight fast. In two subjects levels were undetectable (less than 20 ng/ml). In view of these observations it is suggested that 6-MP should be administered before food if maximum blood levels are to be achieved.
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
April 1987,
Clinical pharmacology and therapeutics,
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
January 1981,
Chemical & pharmaceutical bulletin,
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
January 1963,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
May 1962,
The American journal of pathology,
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
December 2007,
Bioorganic & medicinal chemistry letters,
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
October 1973,
Transplantation,
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
June 1968,
The Australian journal of experimental biology and medical science,
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
October 1966,
Bulletin of the Calcutta School of Tropical Medicine,
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
January 1955,
Giornale italiano di chemioterapia,
N K Burton, and
M J Barnett, and
G W Aherne, and
J Evans, and
I Douglas, and
T A Lister
August 1965,
The Journal of clinical investigation,
