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We found extremely low (6 U/l) serum lactate dehydrogenase (LDH, EC 1.1.1.27) activity in a patient with uterine myoma. The patient's serum inhibited purified LDH isoenzymes. One milliliter serum neutralized 73 U purified LDH-1 isoenzyme, equivalent to 300-500-fold the amount of LDH in 1 ml of normal serum. The serum inhibitor was purified by ordinary procedures using chromatographies and identified as IgG which contains both kappa- and lambda-chains. The IgG is very unique in showing higher affinity to the H- than M-subunit of the LDH tetramer, in contrast with the IgGs already reported. After removal of the myoma, the anti-LDH activity gradually decreased with a half-life of 20 days corresponding to that of IgG and finally almost disappeared. This indicates a possibility that the myoma cells produce some factors such as B-cell growth and differentiation factors.
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
January 1984,
Clinical chemistry,
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
July 1985,
Clinical chemistry,
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
July 1986,
Clinical chemistry,
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
November 1985,
Clinical chemistry,
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
July 1984,
Clinica chimica acta; international journal of clinical chemistry,
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
December 1983,
Hiroshima journal of medical sciences,
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
August 1969,
Scandinavian journal of clinical and laboratory investigation,
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
August 1973,
Clinica chimica acta; international journal of clinical chemistry,
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
July 1986,
Clinical chemistry,
T Hirano, and
H Matsuzaki, and
M Miura, and
E Kojima, and
N Tamura, and
T Sekine
November 1998,
Clinical chemistry,
