Biomaterial Database

Erythromycin prophylaxis for recurrent otitis media. 1986

R M Lampe, and M R Weir

Patients with recurrent otitis media without persistent middle ear effusion were studied for antibiotic prophylaxis efficacy. In the first phase, erythromycin ethylsuccinate was used as prophylaxis for otitis media in 45 patients in a dose of 10 mg/kg twice daily. Acute otitis media occurred in eight of 45 (18%) while receiving erythromycin, and in 22 of 41 (54%) following prophylaxis termination. The attack rate (episodes of otitis media per 2-month period) was 0.86 before prophylaxis, 0.20 during prophylaxis, and 0.79 following prophylaxis. In a second phase of the study, erythromycin was compared with sulfisoxazole for otitis media prophylaxis in a group of 42 children. Sulfisoxazole (500 mg per dose) was administered twice daily. Acute otitis media occurred in five of 28 (18%) children while receiving erythromycin and in nine of 21 (43%) children while receiving no prophylaxis. The attack rate (episodes of otitis media per 2-month period) was 0.81 before erythromycin prophylaxis, 0.18 while receiving erythromycin, and 0.50 after erythromycin prophylaxis. Acute otitis media occurred in eight of 14 (51%) children while receiving sulfisoxazole, and in two of five (40%) children while receiving no prophylaxis. The attack rate (episodes of otitis media per 2-month period) was 0.78 before sulfisoxazole, 0.72 while receiving sulfisoxazole, and 0.56 after sulfisoxazole prophylaxis. Erythromycin antimicrobial prophylaxis for children with recurrent otitis media was superior to no prophylaxis and to sulfisoxazole prophylaxis in this study of patients with recurrent otitis media without persistent middle ear effusion.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008876	Middle Ear Ventilation	Ventilation of the middle ear in the treatment of secretory (serous) OTITIS MEDIA, usually by placement of tubes or grommets which pierce the TYMPANIC MEMBRANE.	Grommet Insertion,Tympanostomy Tube Insertion,Ventilation, Middle Ear,Myringostomy,Tympanostomy,Ear Ventilation, Middle,Ear Ventilations, Middle,Grommet Insertions,Insertion, Grommet,Insertion, Tympanostomy Tube,Insertions, Grommet,Insertions, Tympanostomy Tube,Middle Ear Ventilations,Myringostomies,Tube Insertion, Tympanostomy,Tube Insertions, Tympanostomy,Tympanostomies,Tympanostomy Tube Insertions,Ventilations, Middle Ear
D010033	Otitis Media	Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.	Middle Ear Inflammation,Inflammation, Middle Ear
D012008	Recurrence	The return of a sign, symptom, or disease after a remission.	Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D004917	Erythromycin	A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.	Erycette,Erymax,Erythromycin A,Erythromycin C,Erythromycin Lactate,Erythromycin Phosphate,Ilotycin,T-Stat,Lactate, Erythromycin,Phosphate, Erythromycin,T Stat,TStat
D005260	Female		Females
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006192	Haemophilus Infections	Infections with bacteria of the genus HAEMOPHILUS.	Hemophilus Infections,Haemophilus influenzae Infection,Haemophilus influenzae Type b Infection,Hib Infection,Infections, Haemophilus,Infections, Hemophilus,Haemophilus Infection,Haemophilus influenzae Infections,Hemophilus Infection,Hib Infections,Infection, Haemophilus,Infection, Haemophilus influenzae,Infection, Hemophilus,Infection, Hib
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013444	Sulfisoxazole	A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.	Sulfafurazole,Gantrisin,Gantrisin Pediatric,Neoxazoi,Sulfadimethyloxazole,Sulfafurazol FNA,Sulfasoxizole,Sulfisoxazole Diolamine,Sulfisoxazole, Ammonium Salt,Sulfisoxazole, Monolithium Salt,Sulfisoxazole, Monosodium Salt,Sulfisoxazole, Monosodium, Monomesylate Salt,Sulfisoxazole, Triammonium Salt,TL-azole,V-Sul,Ammonium Salt Sulfisoxazole,Diolamine, Sulfisoxazole,Monolithium Salt Sulfisoxazole,Monosodium Salt Sulfisoxazole,Pediatric, Gantrisin,TL azole,Triammonium Salt Sulfisoxazole,V Sul