Biomaterial Database

[Experimental study on tumor metastasis after treatment by hematoporphyrin derivative and laser]. 1986

J Gao, and S S Qian, and B G Li, and X P Chen

The purpose of the present experiment is to observe whether metastasis will develop after the tumor is treated by hematoporphyrin derivative (HPD) and pulse laser. Mouse transplantable forestomach carcinoma (FC) was used of which the spontaneous metastasis rate was 33% to 83%. 179 inbred "615" mice were divided into six groups for repeated experiments. The first repeated experiment included three groups: group 1, pulse laser with HPD; group 2, continuous laser with HPD; group 3, control. The second repeated experiment also included three groups: group 4, pulse laser without HPD; group 5, pulse laser with HPD and group 6, control. On day 5 after FC transplantation, the animals of group 1, 2 and 5 were injected intraperitoneally with HPD (50mg/kg) and then group 1, 2, 4 and 5 were treated with laser on day 7. From group 1, 2 and 3, 10 animals were sacrificed on day 12 and the rest animals on day 16. The lymph nodes and lungs of all animals were taken out for gross and histological examination. It was found that the tumor metastasis rates of the six groups were: group 1, 32.3% (10/31); group 2, 21.8% (7/32); group 3, 38.1% (8/22); group 4, 64.0% (16/25); group 5, 74.1% (20/27) and group 6, 83.3% (35/42). It shows that laser does not increase the incidence of tumor metastasis.

UI	MeSH Term	Description	Entries
D007834	Lasers	An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.	Masers,Continuous Wave Lasers,Pulsed Lasers,Q-Switched Lasers,Continuous Wave Laser,Laser,Laser, Continuous Wave,Laser, Pulsed,Laser, Q-Switched,Lasers, Continuous Wave,Lasers, Pulsed,Lasers, Q-Switched,Maser,Pulsed Laser,Q Switched Lasers,Q-Switched Laser
D008175	Lung Neoplasms	Tumors or cancer of the LUNG.	Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D008297	Male		Males
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D010778	Photochemotherapy	Therapy using oral or topical photosensitizing agents with subsequent exposure to light.	Blue Light Photodynamic Therapy,Photodynamic Therapy,Red Light PDT,Red Light Photodynamic Therapy,Therapy, Photodynamic,Light PDT, Red,PDT, Red Light,Photochemotherapies,Photodynamic Therapies,Therapies, Photodynamic
D005260	Female		Females
D006414	Hematoporphyrin Photoradiation	Photochemotherapy using visible light, usually red, topically or delivered locally by fiberoptic probe to tissues sensitized with hematoporphyrins.	Photochemotherapy, Hematoporphyrin,Photoradiation, Hematoporphyrin,Hematoporphyrin Photochemotherapy
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013274	Stomach Neoplasms	Tumors or cancer of the STOMACH.	Cancer of Stomach,Gastric Cancer,Gastric Neoplasms,Stomach Cancer,Cancer of the Stomach,Gastric Cancer, Familial Diffuse,Neoplasms, Gastric,Neoplasms, Stomach,Cancer, Gastric,Cancer, Stomach,Cancers, Gastric,Cancers, Stomach,Gastric Cancers,Gastric Neoplasm,Neoplasm, Gastric,Neoplasm, Stomach,Stomach Cancers,Stomach Neoplasm
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus