Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility. 2023

Lori B Dershowitz, and Hassler Bueno Garcia, and Andrew S Perley, and Todd P Coleman, and Julia A Kaltschmidt
Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 USA.

Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients.

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