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Cognitive impairment and dementia in young onset Parkinson's disease. 2023
Diego Santos-García, and
Teresa de Deus Fonticoba, and
Carlos Cores Bartolomé, and
María J Feal Painceiras, and
Iago García Díaz, and
María Cristina Íñiguez Alvarado, and
Jose Manuel Paz, and
Silvia Jesús, and
Marina Cosgaya, and
Juan García Caldentey, and
Nuria Caballol, and
Ines Legarda, and
Jorge Hernández Vara, and
Iria Cabo, and
Lydia López Manzanares, and
Isabel González Aramburu, and
Maria A Ávila Rivera, and
Víctor Gómez Mayordomo, and
Víctor Nogueira, and
Julio Dotor García-Soto, and
Carmen Borrué, and
Berta Solano Vila, and
María Álvarez Sauco, and
Lydia Vela, and
Sonia Escalante, and
Esther Cubo, and
Zebenzui Mendoza, and
Juan C Martínez Castrillo, and
Pilar Sánchez Alonso, and
Maria G Alonso Losada, and
Nuria López Ariztegui, and
Itziar Gastón, and
Jaime Kulisevsky, and
Manuel Seijo, and
Caridad Valero, and
Ruben Alonso Redondo, and
Maria Teresa Buongiorno, and
Carlos Ordás, and
Manuel Menéndez-González, and
Darrian McAfee, and
Pablo Martinez-Martin, and
Pablo Mir, and
CHUAC, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain. diegosangar@yahoo.es.
OBJECTIVE Patients with young-onset Parkinson's disease (YOPD) have a slower progression. Our aim was to analyze the change in cognitive function in YOPD compared to patients with a later onset and controls. METHODS Patients with Parkinson's disease (PD) and controls from the COPPADIS cohort were included. Cognitive function was assessed with the Parkinson's Disease Cognitive Rating Scale (PD-CRS) at baseline (V0), 2-year ± 1 month (V2y), and 4-year ± 3 months follow-up (V4y). Regarding age from symptoms onset, patients were classified as YOPD (< 50 years) or non-YOPD (≥ 50). A score in the PD-CRS < 81 was defined as cognitive impairment (CI): ≤ 64 dementia; 65-80 mild cognitive impairment (MCI). RESULTS One-hundred and twenty-four YOPD (50.7 ± 7.9 years; 66.1% males), 234 non-YOPD (67.8 ± 7.8 years; 59.3% males) patients, and 205 controls (61 ± 8.3 years; 49.5% males) were included. The score on the PD-CRS and its subscore domains was higher at all visits in YOPD compared to non-YOPD patients and to controls (p < 0.0001 in all analysis), but no differences were detected between YOPD patients and controls. Only non-YOPD patients had significant impairment in their cognitive function from V0 to V4y (p < 0.0001). At V4y, the frequency of dementia and MCI was 5% and 10% in YOPD compared to 25.2% and 22.3% in non-YOPD patients (p < 0.0001). A lower score on the Parkinson's Disease Sleep Scale at baseline was a predictor of CI at V4y in YOPD patients (Adjusted R2 = 0.61; OR = 0.965; p = 0.029). CONCLUSIONS Cognitive dysfunction progressed more slowly in YOPD than in non-YOPD patients.
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