-transparent.png){kind=logo}
A cup of coffee contains mutagens which produce about 5 X 10(4)-10(5) revertants of Salmonella typhimurium TA 100 without S9 mix. One of the mutagens was identified to be methylglyoxal. Methylglyoxal was present in various beverages such as black tea, whisky, and brandy. Methylglyoxal itself induced tumors in rats when administered by subcutaneous injection. However, the mutagenic properties of coffee were different from those of methylglyoxal. The mutagenicity of coffee was suppressed by catalase, and coffee was found to contain hydrogen peroxide. Furthermore, coffee solution was found to have a hydrogen peroxide-generating system. Instant coffee (15 mg/mL) contains 130 microM hydrogen peroxide immediately after the dissolution of coffee powder in water at room temperature. The concentration of hydrogen peroxide increased with time. The mutagenicity of methylglyoxal was increased by the copresence of hydrogen peroxide. A maximum of 30-fold enhancement was observed. The mutagenicity of black tea but not that of whisky was suppressed by catalase.
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
October 1979,
Mutation research,
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
June 1966,
Proceedings of the National Academy of Sciences of the United States of America,
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
October 1995,
Free radical research,
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
January 2018,
Addiction (Abingdon, England),
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
December 2021,
Scientific reports,
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
August 2014,
Hepatology (Baltimore, Md.),
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
September 1997,
Epidemiology (Cambridge, Mass.),
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
May 1986,
International journal of cancer,
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
November 1980,
Mutation research,
M Nagao, and
Y Fujita, and
K Wakabayashi, and
H Nukaya, and
T Kosuge, and
T Sugimura
March 1983,
Journal of the science of food and agriculture,
