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Through three generations, male rats were fed a commercial chow supplemented with four levels of methyl mercury; the average mercury concentrations were 0.038, 0.18, 7.23, and 33.92 nmol Hg/g food for control, low, middle, and high dose groups, respectively. No clinical abnormalities except enlarged kidneys were found in these animals. The effects of dose and generation on tissue distribution and accumulation of inorganic mercury and total mercury were studied in the brain, kidneys, and liver. The dose level of methyl mercury greatly determined the organ accumulation of total mercury and inorganic mercury, as well as the ratio of inorganic mercury concentration to total mercury concentration (I/T) in organs. The I/T ratio was inversely related to the dose level of methyl mercury. With generational procession, the most notable change was found in the liver, i.e., the increasing I/T ratio and the decreasing total mercury accumulation at any dose level. In contrast, the I/T ratio in the kidney showed no constant tendency with generation. The present results suggest that the generational enhancement of inorganic mercury formation from methyl mercury occurs mainly in the liver.
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
January 1989,
Biological trace element research,
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
April 1980,
Archives of toxicology,
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
December 2006,
The Tohoku journal of experimental medicine,
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
October 2011,
Environmental pollution (Barking, Essex : 1987),
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
April 1987,
Environmental research,
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
October 2005,
Environmental health perspectives,
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
November 1990,
Bulletin of environmental contamination and toxicology,
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
August 1991,
Ugeskrift for laeger,
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
October 1995,
Bulletin of environmental contamination and toxicology,
R Yamamoto, and
T Suzuki, and
H Satoh, and
K Kawai
June 1973,
Experimental and molecular pathology,
