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In order to investigate how growth factors stimulate DNA synthesis, we studied the relationship between early increases in the intracellular concentration of free calcium (Cai) and early mitogenic events (competence) in quiescent BALB/c 3T3 cells. Cai was measured by aequorin luminescence, and DNA synthesis was quantitated by autoradiography. While both serum (2%) and platelet-derived growth factor (2 U/ml) stimulated large increases in Cai without inducing competence, fibroblast growth factor (100-400 ng/ml) produced a large number of competent cells without causing a detectable increase in Cai. Thus, there was no correlation between the magnitude of Cai increase and subsequent competence for DNA synthesis.
R W Tucker, and
K W Snowdowne, and
A B Borle
November 1984,
The American journal of physiology,
R W Tucker, and
K W Snowdowne, and
A B Borle
January 1991,
The Journal of biological chemistry,
R W Tucker, and
K W Snowdowne, and
A B Borle
January 1990,
Folia haematologica (Leipzig, Germany : 1928),
R W Tucker, and
K W Snowdowne, and
A B Borle
January 1982,
Journal of cellular biochemistry,
R W Tucker, and
K W Snowdowne, and
A B Borle
October 1991,
The Biological bulletin,
R W Tucker, and
K W Snowdowne, and
A B Borle
April 1982,
Experimental neurology,
R W Tucker, and
K W Snowdowne, and
A B Borle
April 1981,
Journal of cellular physiology,
R W Tucker, and
K W Snowdowne, and
A B Borle
February 1990,
European journal of cell biology,
R W Tucker, and
K W Snowdowne, and
A B Borle
February 1980,
Experimental cell research,
R W Tucker, and
K W Snowdowne, and
A B Borle
January 1983,
Journal of submicroscopic cytology,
