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Basal, 5'-guanylimidodiphosphate, GTP-, NaF-, forskolin-, D,L-isoproterenol-, glucagon- and secretin-stimulated adenylate cyclase activities were investigated in cardiac membranes from young adult (6 month old), old (20 month old) and senescent (24 month old) Sprague Dawley rats. The only significant difference between old and young adult rats was a 43% decrease of the glucagon-stimulated enzyme activity. In senescent rats compared to young adult rats, we observed a 23% decrease in forskolin-stimulated enzyme activity, a more severe (-73%) decrease in glucagon-stimulated adenylate cyclase activity and a decrease (-38%) of the response to secretin. The response to the beta-adrenoreceptor agonist D,L-isoproterenol was unaffected. These results suggest an alteration with age in the vicinity of the catalytic unit of adenylate cyclase and a selective decrease of functional glucagon and secretin receptors.
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
January 1985,
The Canadian journal of cardiology,
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
March 1974,
Biochimica et biophysica acta,
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
May 1981,
Mechanisms of ageing and development,
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
January 1986,
The Journal of membrane biology,
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
October 1980,
Archives of biochemistry and biophysics,
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
December 1975,
Biochemical pharmacology,
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
November 1978,
European journal of pharmacology,
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
September 1987,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
January 1987,
Journal of molecular and cellular cardiology,
P Robberecht, and
M Gillard, and
M Waelbroeck, and
J C Camus, and
P De Neef, and
J Christophe
January 1983,
Mechanisms of ageing and development,
