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The effects of single and long-term administration of apomorphine (AP) and amphetamine (AM) on the locomotor behaviour of rats observed in an open-field (LF), and on the locomotion stereotyped behaviour (LSB) of rats were compared in the present study. Single AP treatment did not modify LF and LSB. Single AM treatment reduced the duration of LSB 2 and 3 days after drug administration, but did not alter the LF. Long-term treatment with both drugs reduced the inhibitory effects of low AP doses on open-field behaviour. Subsensitivity of dopaminergic autoreceptors induced by the long-term dopaminergic agonist administration was considered to be involved in the differences observed.
M M Bernardi, and
C Scavone, and
R Frussa-Filho
January 1985,
Psychopharmacology,
M M Bernardi, and
C Scavone, and
R Frussa-Filho
July 1981,
Brain research,
M M Bernardi, and
C Scavone, and
R Frussa-Filho
January 1977,
Communications in psychopharmacology,
M M Bernardi, and
C Scavone, and
R Frussa-Filho
January 1983,
General pharmacology,
M M Bernardi, and
C Scavone, and
R Frussa-Filho
November 1987,
Pharmacology, biochemistry, and behavior,
M M Bernardi, and
C Scavone, and
R Frussa-Filho
September 1988,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
M M Bernardi, and
C Scavone, and
R Frussa-Filho
January 1984,
Progress in neuro-psychopharmacology & biological psychiatry,
M M Bernardi, and
C Scavone, and
R Frussa-Filho
January 1993,
Psychopharmacology,
M M Bernardi, and
C Scavone, and
R Frussa-Filho
June 1978,
Journal of medicinal chemistry,
M M Bernardi, and
C Scavone, and
R Frussa-Filho
December 1974,
Brain research,
