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Insulin antibody production was studied in two groups of 9 adult diabetics each, who were never treated before with insulin. One group received Monocomponent porcine lente insulin (MC) and the other group single peak beef NPH insulin, for 3 years. Insulin antibodies were evaluated by antibody-bound immunoreactive insulin (Abl) and by the labelled insulin binding capacity (IBC) which presented a significant correlation best fitted by a logarithmic curve. The patients treated with MC insulin developed significant levels of insulin antibodies, however, at lower levels and appearing later in comparison to those with beef NPH. Only 3 patients did not produce significant levels of insulin antibodies. The highest titers occurred after different lengths of treatment in the two groups of patients. Abl decreased after continuation of treatment particularly in the MC series. While in the MC-treated patients there was some positive correlation between the insulin dose and the level of Abl no significant correlation was found between the diabetes control and insulin antibody titers in both groups of patients.
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
January 1977,
Panminerva medica,
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
November 1987,
Zhonghua nei ke za zhi,
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
February 1958,
Bruxelles medical,
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
April 1978,
Minerva medica,
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
January 1984,
Minerva endocrinologica,
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
January 1974,
The Netherlands journal of medicine,
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
January 1987,
Diabetic medicine : a journal of the British Diabetic Association,
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
September 2018,
The Veterinary record,
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
March 1986,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
B L Wajchenberg, and
Y G Thomsen, and
I T Toledo e Souza, and
O A Germek
May 1983,
MMW, Munchener medizinische Wochenschrift,
