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Nutritional intake is an important regulator of plasma somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) concentrations in plasma. Concentrations in humans are reduced to the hypopituitary range by fasting for only a few days, and their normalization after fasting depends on the adequacy of energy and protein in the refeeding diet. The changes correlate with changes in nitrogen balance. In rats we have observed a close relationship between change in plasma Sm-C/IGF-I and hepatic GH binding with fasting and refeeding, suggesting that alterations in GH binding might be responsible partly for changes in Sm-C/IGF-I. When malnourished humans are given nutrient repletion, the increase in Sm-C/IGF-I is far more dramatic than changes in other nutrient-related serum proteins.
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
August 2002,
Nihon rinsho. Japanese journal of clinical medicine,
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
January 1987,
Methods in enzymology,
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
January 1985,
Methods in enzymology,
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
April 1983,
Proceedings of the National Academy of Sciences of the United States of America,
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
January 1986,
Molecular biology reports,
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
April 1988,
Endocrinology,
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
October 1986,
Endocrinology,
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
July 1986,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
February 1982,
The Journal of clinical endocrinology and metabolism,
L E Underwood, and
D R Clemmons, and
M Maes, and
A J D'Ercole, and
J M Ketelslegers
January 1987,
Reproduction, nutrition, developpement,
