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Yolk sac cell atlas reveals multiorgan functions during human early development. 2023
Issac Goh, and
Rachel A Botting, and
Antony Rose, and
Simone Webb, and
Justin Engelbert, and
Yorick Gitton, and
Emily Stephenson, and
Mariana Quiroga Londoño, and
Michael Mather, and
Nicole Mende, and
Ivan Imaz-Rosshandler, and
Lu Yang, and
Dave Horsfall, and
Daniela Basurto-Lozada, and
Nana-Jane Chipampe, and
Victoria Rook, and
Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
Pavel Mazin, and
M S Vijayabaskar, and
Rebecca Hannah, and
Laure Gambardella, and
Kile Green, and
Stephane Ballereau, and
Megumi Inoue, and
Elizabeth Tuck, and
Valentina Lorenzi, and
Kwasi Kwakwa, and
Clara Alsinet, and
Bayanne Olabi, and
Mohi Miah, and
Chloe Admane, and
Dorin-Mirel Popescu, and
Meghan Acres, and
David Dixon, and
Thomas Ness, and
Rowen Coulthard, and
Steven Lisgo, and
Deborah J Henderson, and
Emma Dann, and
Chenqu Suo, and
Sarah J Kinston, and
Jong-Eun Park, and
Krzysztof Polanski, and
John Marioni, and
Stijn van Dongen, and
Kerstin B Meyer, and
Marella de Bruijn, and
James Palis, and
Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
Omer Bayraktar, and
Irene Roberts, and
Laura Jardine, and
Berthold Göttgens, and
Sarah A Teichmann, and
Muzlifah Haniffa
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds.
Related Publications
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Rachel A Botting, and
Antony Rose, and
Simone Webb, and
Justin Engelbert, and
Yorick Gitton, and
Emily Stephenson, and
Mariana Quiroga Londoño, and
Michael Mather, and
Nicole Mende, and
Ivan Imaz-Rosshandler, and
Lu Yang, and
Dave Horsfall, and
Daniela Basurto-Lozada, and
Nana-Jane Chipampe, and
Victoria Rook, and
Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
Pavel Mazin, and
M S Vijayabaskar, and
Rebecca Hannah, and
Laure Gambardella, and
Kile Green, and
Stephane Ballereau, and
Megumi Inoue, and
Elizabeth Tuck, and
Valentina Lorenzi, and
Kwasi Kwakwa, and
Clara Alsinet, and
Bayanne Olabi, and
Mohi Miah, and
Chloe Admane, and
Dorin-Mirel Popescu, and
Meghan Acres, and
David Dixon, and
Thomas Ness, and
Rowen Coulthard, and
Steven Lisgo, and
Deborah J Henderson, and
Emma Dann, and
Chenqu Suo, and
Sarah J Kinston, and
Jong-Eun Park, and
Krzysztof Polanski, and
John Marioni, and
Stijn van Dongen, and
Kerstin B Meyer, and
Marella de Bruijn, and
James Palis, and
Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
Omer Bayraktar, and
Irene Roberts, and
Laura Jardine, and
Berthold Göttgens, and
Sarah A Teichmann, and
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Rachel A Botting, and
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Simone Webb, and
Justin Engelbert, and
Yorick Gitton, and
Emily Stephenson, and
Mariana Quiroga Londoño, and
Michael Mather, and
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Lu Yang, and
Dave Horsfall, and
Daniela Basurto-Lozada, and
Nana-Jane Chipampe, and
Victoria Rook, and
Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
Pavel Mazin, and
M S Vijayabaskar, and
Rebecca Hannah, and
Laure Gambardella, and
Kile Green, and
Stephane Ballereau, and
Megumi Inoue, and
Elizabeth Tuck, and
Valentina Lorenzi, and
Kwasi Kwakwa, and
Clara Alsinet, and
Bayanne Olabi, and
Mohi Miah, and
Chloe Admane, and
Dorin-Mirel Popescu, and
Meghan Acres, and
David Dixon, and
Thomas Ness, and
Rowen Coulthard, and
Steven Lisgo, and
Deborah J Henderson, and
Emma Dann, and
Chenqu Suo, and
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Jong-Eun Park, and
Krzysztof Polanski, and
John Marioni, and
Stijn van Dongen, and
Kerstin B Meyer, and
Marella de Bruijn, and
James Palis, and
Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
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Irene Roberts, and
Laura Jardine, and
Berthold Göttgens, and
Sarah A Teichmann, and
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Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
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Irene Roberts, and
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Mariana Quiroga Londoño, and
Michael Mather, and
Nicole Mende, and
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Lu Yang, and
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Daniela Basurto-Lozada, and
Nana-Jane Chipampe, and
Victoria Rook, and
Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
Pavel Mazin, and
M S Vijayabaskar, and
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Laure Gambardella, and
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Megumi Inoue, and
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Kwasi Kwakwa, and
Clara Alsinet, and
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Mohi Miah, and
Chloe Admane, and
Dorin-Mirel Popescu, and
Meghan Acres, and
David Dixon, and
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Steven Lisgo, and
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Emma Dann, and
Chenqu Suo, and
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Krzysztof Polanski, and
John Marioni, and
Stijn van Dongen, and
Kerstin B Meyer, and
Marella de Bruijn, and
James Palis, and
Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
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Irene Roberts, and
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Sarah A Teichmann, and
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Daniela Basurto-Lozada, and
Nana-Jane Chipampe, and
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Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
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Clara Alsinet, and
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Mohi Miah, and
Chloe Admane, and
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Meghan Acres, and
David Dixon, and
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Kerstin B Meyer, and
Marella de Bruijn, and
James Palis, and
Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
Omer Bayraktar, and
Irene Roberts, and
Laura Jardine, and
Berthold Göttgens, and
Sarah A Teichmann, and
Muzlifah Haniffa
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Mariana Quiroga Londoño, and
Michael Mather, and
Nicole Mende, and
Ivan Imaz-Rosshandler, and
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Nana-Jane Chipampe, and
Victoria Rook, and
Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
Pavel Mazin, and
M S Vijayabaskar, and
Rebecca Hannah, and
Laure Gambardella, and
Kile Green, and
Stephane Ballereau, and
Megumi Inoue, and
Elizabeth Tuck, and
Valentina Lorenzi, and
Kwasi Kwakwa, and
Clara Alsinet, and
Bayanne Olabi, and
Mohi Miah, and
Chloe Admane, and
Dorin-Mirel Popescu, and
Meghan Acres, and
David Dixon, and
Thomas Ness, and
Rowen Coulthard, and
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Krzysztof Polanski, and
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Stijn van Dongen, and
Kerstin B Meyer, and
Marella de Bruijn, and
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Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
Omer Bayraktar, and
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Muzlifah Haniffa
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Michael Mather, and
Nicole Mende, and
Ivan Imaz-Rosshandler, and
Lu Yang, and
Dave Horsfall, and
Daniela Basurto-Lozada, and
Nana-Jane Chipampe, and
Victoria Rook, and
Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
Pavel Mazin, and
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Laure Gambardella, and
Kile Green, and
Stephane Ballereau, and
Megumi Inoue, and
Elizabeth Tuck, and
Valentina Lorenzi, and
Kwasi Kwakwa, and
Clara Alsinet, and
Bayanne Olabi, and
Mohi Miah, and
Chloe Admane, and
Dorin-Mirel Popescu, and
Meghan Acres, and
David Dixon, and
Thomas Ness, and
Rowen Coulthard, and
Steven Lisgo, and
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Emma Dann, and
Chenqu Suo, and
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Jong-Eun Park, and
Krzysztof Polanski, and
John Marioni, and
Stijn van Dongen, and
Kerstin B Meyer, and
Marella de Bruijn, and
James Palis, and
Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
Omer Bayraktar, and
Irene Roberts, and
Laura Jardine, and
Berthold Göttgens, and
Sarah A Teichmann, and
Muzlifah Haniffa
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Antony Rose, and
Simone Webb, and
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Emily Stephenson, and
Mariana Quiroga Londoño, and
Michael Mather, and
Nicole Mende, and
Ivan Imaz-Rosshandler, and
Lu Yang, and
Dave Horsfall, and
Daniela Basurto-Lozada, and
Nana-Jane Chipampe, and
Victoria Rook, and
Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
Pavel Mazin, and
M S Vijayabaskar, and
Rebecca Hannah, and
Laure Gambardella, and
Kile Green, and
Stephane Ballereau, and
Megumi Inoue, and
Elizabeth Tuck, and
Valentina Lorenzi, and
Kwasi Kwakwa, and
Clara Alsinet, and
Bayanne Olabi, and
Mohi Miah, and
Chloe Admane, and
Dorin-Mirel Popescu, and
Meghan Acres, and
David Dixon, and
Thomas Ness, and
Rowen Coulthard, and
Steven Lisgo, and
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Emma Dann, and
Chenqu Suo, and
Sarah J Kinston, and
Jong-Eun Park, and
Krzysztof Polanski, and
John Marioni, and
Stijn van Dongen, and
Kerstin B Meyer, and
Marella de Bruijn, and
James Palis, and
Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
Omer Bayraktar, and
Irene Roberts, and
Laura Jardine, and
Berthold Göttgens, and
Sarah A Teichmann, and
Muzlifah Haniffa
September 1983,
Nihon Sanka Fujinka Gakkai zasshi,
Issac Goh, and
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Antony Rose, and
Simone Webb, and
Justin Engelbert, and
Yorick Gitton, and
Emily Stephenson, and
Mariana Quiroga Londoño, and
Michael Mather, and
Nicole Mende, and
Ivan Imaz-Rosshandler, and
Lu Yang, and
Dave Horsfall, and
Daniela Basurto-Lozada, and
Nana-Jane Chipampe, and
Victoria Rook, and
Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
Pavel Mazin, and
M S Vijayabaskar, and
Rebecca Hannah, and
Laure Gambardella, and
Kile Green, and
Stephane Ballereau, and
Megumi Inoue, and
Elizabeth Tuck, and
Valentina Lorenzi, and
Kwasi Kwakwa, and
Clara Alsinet, and
Bayanne Olabi, and
Mohi Miah, and
Chloe Admane, and
Dorin-Mirel Popescu, and
Meghan Acres, and
David Dixon, and
Thomas Ness, and
Rowen Coulthard, and
Steven Lisgo, and
Deborah J Henderson, and
Emma Dann, and
Chenqu Suo, and
Sarah J Kinston, and
Jong-Eun Park, and
Krzysztof Polanski, and
John Marioni, and
Stijn van Dongen, and
Kerstin B Meyer, and
Marella de Bruijn, and
James Palis, and
Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
Omer Bayraktar, and
Irene Roberts, and
Laura Jardine, and
Berthold Göttgens, and
Sarah A Teichmann, and
Muzlifah Haniffa
March 1981,
The American journal of anatomy,
Issac Goh, and
Rachel A Botting, and
Antony Rose, and
Simone Webb, and
Justin Engelbert, and
Yorick Gitton, and
Emily Stephenson, and
Mariana Quiroga Londoño, and
Michael Mather, and
Nicole Mende, and
Ivan Imaz-Rosshandler, and
Lu Yang, and
Dave Horsfall, and
Daniela Basurto-Lozada, and
Nana-Jane Chipampe, and
Victoria Rook, and
Jimmy Tsz Hang Lee, and
Mai-Linh Ton, and
Daniel Keitley, and
Pavel Mazin, and
M S Vijayabaskar, and
Rebecca Hannah, and
Laure Gambardella, and
Kile Green, and
Stephane Ballereau, and
Megumi Inoue, and
Elizabeth Tuck, and
Valentina Lorenzi, and
Kwasi Kwakwa, and
Clara Alsinet, and
Bayanne Olabi, and
Mohi Miah, and
Chloe Admane, and
Dorin-Mirel Popescu, and
Meghan Acres, and
David Dixon, and
Thomas Ness, and
Rowen Coulthard, and
Steven Lisgo, and
Deborah J Henderson, and
Emma Dann, and
Chenqu Suo, and
Sarah J Kinston, and
Jong-Eun Park, and
Krzysztof Polanski, and
John Marioni, and
Stijn van Dongen, and
Kerstin B Meyer, and
Marella de Bruijn, and
James Palis, and
Sam Behjati, and
Elisa Laurenti, and
Nicola K Wilson, and
Roser Vento-Tormo, and
Alain Chédotal, and
Omer Bayraktar, and
Irene Roberts, and
Laura Jardine, and
Berthold Göttgens, and
Sarah A Teichmann, and
Muzlifah Haniffa
September 2023,
Cell,
