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One-Pot Stereoselective Synthesis of Furantetrahydroquinoline Derivatives Using d/l-Ribose with a 2,3-O-Isopropylidene Group. 2023
Jilai Wu, and
Song Xie, and
Likai Zhou, and
Yixuan Liu, and
Yaxin Cui, and
Xiaoyan Huang, and
Chao Wei, and
Xiaoliu Li, and
Chunfang Zhang, and
Hua Chen
Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Material Science, Hebei University, Baoding, Hebei 071002, P. R. China.
An efficient and convenient strategy has been successfully developed for the preparation of novel furantetrahydroquinoline derivatives using d/l-ribose with a 2,3-O-isopropylidene group through the aza-Diels-Alder mechanism. This method has high atom and step economy, high stereoselectivity, and gram-scale synthesis (yield 67%).
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