-transparent.png){kind=logo}
9,11-Iminoepoxyprosta-5,13-dienoic acid inhibits the thromboxane A2 synthetase in platelet and lung microsomal enzyme preparations and in intact platelets. It does not inhibit the protaglandin I2 synthetase in aorta or lung microsomes and intact Balb 3T3 fibroblasts. In lung microsomes, which contain both enzymes, 9,11-iminoepoxyprosta-5,13-dienoic acid inhibits only thromboxane A2 formation and augments prostaglandin I2 formation. This inhibitor is more selective than other reported prostaglandin endoperoxide analogs which inhibit the platelet thromboxane synthetase.
Related Publications
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
January 1986,
Thrombosis research,
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
September 1988,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
October 1987,
Biochemical and biophysical research communications,
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
January 1986,
Nihon geka hokan. Archiv fur japanische Chirurgie,
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
January 1984,
Nephron,
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
June 1987,
Nihon Jinzo Gakkai shi,
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
November 1996,
Nihon rinsho. Japanese journal of clinical medicine,
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
January 1984,
Stroke,
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
April 1977,
Prostaglandins,
F Fitzpatrick, and
R Gorman, and
G Bundy, and
T Honohan, and
J McGuire, and
F Sun
May 1996,
The Journal of surgical research,
