-transparent.png){kind=logo}
Glial-derived mitochondrial signals impact neuronal proteostasis and aging. 2023
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
Department of Molecular & Cellular Biology, Howard Hughes Medical Institute, The University of California, Berkeley, Berkeley CA 94720, USA.
The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response (UPRMT), between tissues. However, these studies largely ignored non-neuronal cells of the nervous system. Here, we found that UPRMT activation in four, astrocyte-like glial cells in the nematode, C. elegans, can promote protein homeostasis by alleviating protein aggregation in neurons. Surprisingly, we find that glial cells utilize small clear vesicles (SCVs) to signal to neurons, which then relay the signal to the periphery using dense-core vesicles (DCVs). This work underlines the importance of glia in establishing and regulating protein homeostasis within the nervous system, which can then impact neuron-mediated effects in organismal homeostasis and longevity.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
August 2014,
Cell metabolism,
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
January 1975,
Federation proceedings,
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
December 2015,
Nature medicine,
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
January 1981,
Neurochemical research,
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
April 2019,
The Journal of biological chemistry,
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
April 2015,
Seminars in cell & developmental biology,
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
February 2020,
Cell reports,
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
January 1987,
Journal de physiologie,
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
October 2017,
Redox biology,
Raz Bar-Ziv, and
Naibedya Dutta, and
Adam Hruby, and
Edward Sukarto, and
Maxim Averbukh, and
Athena Alcala, and
Hope R Henderson, and
Jenni Durieux, and
Sarah U Tronnes, and
Qazi Ahmad, and
Theodore Bolas, and
Joel Perez, and
Julian G Dishart, and
Matthew Vega, and
Gilberto Garcia, and
Ryo Higuchi-Sanabria, and
Andrew Dillin
November 2017,
Cell reports,
