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Patients with stage III and IV melanoma were randomly assigned to receive procarbazine (100 mg/m2, Days 1--10), vinblastine (5 mg/m2, Days 1 and 8), and actinomycin D (0.5 mg/m2, Days 1 and 8) with or without methanol-extracted residue (MER) of bacillus Calmette-Guerin (200 micrograms in five sites). In patients with measurable disease, 20% (eight of 40 patients) responded with only the combination chemotherapy while 15% (six of 39 patients) responded with the MER added. Toxicity was tolerable except for some instances of severe, gastrointestinal toxicity associated with procarbazine. MER as given in this study, failed to either increase the response rate or prolong survival.
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
April 1978,
Cancer treatment reports,
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
April 1978,
Cancer treatment reports,
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
January 1979,
Cancer treatment reports,
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
March 1973,
Cancer research,
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
August 1977,
Cancer treatment reports,
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
January 1979,
Cancer treatment reports,
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
April 1977,
Cancer research,
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
October 1979,
The Journal of antibiotics,
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
January 1977,
Cancer treatment reports,
J E Kostinas, and
L A Leone, and
J Cuttner, and
V Vinciguerra, and
M Green, and
R De Bellis, and
T F Pajak
January 1975,
Cancer chemotherapy reports,
