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An improved method for the determination of urinary delta-aminolevulinic acid (ALA) as an indicator of lead absorption is described. It is a modification of the analytical procedure described by Tomokuni and Ogata in 1972. In the present method, the spot urine from lead-exposed workers which was diluted 3-fold with distilled water beforehand was used as the sample to eliminate as much as possible the urinary matrix interference. In addition, methyl acetoacetate was used as the condensation reagent for ALA-pyrrole, because the color intensity of ALA-pyrrole was higher with the use of methyl acetoacetate than that with ethyl acetoacetate which was used in the original method. The urinary ALA value determined by the present method was similar to that measured using an internal-standard addition method. This method is suitable as a rapid and inexpensive screening procedure for the routine quantitative analysis of urinary ALA.
K Tomokuni, and
N Hasegawa, and
E Sugawara
January 1988,
Sangyo igaku. Japanese journal of industrial health,
K Tomokuni, and
N Hasegawa, and
E Sugawara
January 1973,
Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete,
K Tomokuni, and
N Hasegawa, and
E Sugawara
January 1991,
American journal of industrial medicine,
K Tomokuni, and
N Hasegawa, and
E Sugawara
December 1969,
Internationales Archiv fur Arbeitsmedizin,
K Tomokuni, and
N Hasegawa, and
E Sugawara
August 1995,
Clinical biochemistry,
K Tomokuni, and
N Hasegawa, and
E Sugawara
July 1967,
Archives of environmental health,
K Tomokuni, and
N Hasegawa, and
E Sugawara
January 1973,
Zeitschrift fur medizinische Labortechnik,
K Tomokuni, and
N Hasegawa, and
E Sugawara
March 1969,
Clinical chemistry,
K Tomokuni, and
N Hasegawa, and
E Sugawara
September 1998,
Biological trace element research,
K Tomokuni, and
N Hasegawa, and
E Sugawara
January 1980,
Archiv fur experimentelle Veterinarmedizin,
