-transparent.png){kind=logo}
The interactions of milrinone, ouabain and calcium on force of contraction in isolated, contracting human papillary muscle strips were measured. Milrinone (EC50, 8 X 10(-5)M) increased force of contraction maximally by 2.8 +/- 0.8 mN at 5 X 10(-4)M; significantly less than either ouabain (1 X 10(-7)M; 4.8 +/- 0.5 mN increase) or calcium (15 mM; 6.2 +/- 0.6 mN increase). A submaximal, but not a maximal, inotropic effect of ouabain could be increased by the addition of milrinone; in contrast, both ouabain and calcium increased the maximal inotropic effect of milrinone by 1.7 +/- 0.2 mN and 2.7 +/- 0.3 mN, respectively. The combined inotropic effect of milrinone with either ouabain of 4.2 +/- 0.3 mN or calcium of 5.6 +/- 0.4 mN was not different from that with calcium or ouabain alone. We conclude that further positive inotropic effects should be expected when digitalis is given to patients with congestive heart failure who are already optimally treated with milrinone.
L Brown, and
M Näbauer, and
E Erdmann
July 1986,
Cardiovascular research,
L Brown, and
M Näbauer, and
E Erdmann
January 1994,
Cardiology,
L Brown, and
M Näbauer, and
E Erdmann
May 1984,
Klinische Wochenschrift,
L Brown, and
M Näbauer, and
E Erdmann
June 1996,
The Journal of pharmacology and experimental therapeutics,
L Brown, and
M Näbauer, and
E Erdmann
July 1978,
The Journal of physiology,
L Brown, and
M Näbauer, and
E Erdmann
February 1997,
European journal of pharmacology,
L Brown, and
M Näbauer, and
E Erdmann
October 1994,
Journal of cardiovascular pharmacology,
L Brown, and
M Näbauer, and
E Erdmann
January 1984,
Transactions of the Association of American Physicians,
L Brown, and
M Näbauer, and
E Erdmann
February 1991,
American journal of hypertension,
L Brown, and
M Näbauer, and
E Erdmann
February 1964,
Sbornik lekarsky,
