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Escape from dexamethasone-induced suppression of plasma cortisol is an abnormality found in about half of patients with major depression. It has been hypothesized that this hyperactivity of the hypothalamo-pituitary-adrenal axis might be related to a central noradrenergic hypofunction. The present study was designed to test this hypothesis by measuring plasma 3,4-dihydroxyphenylethyleneglycol (DOPEG) levels (free and conjugated forms), an index of central noradrenergic activity, and by simultaneously carrying out a dexamethasone suppression test. Forty-five patients with a diagnosis of major depression (according to the DSM-III) were investigated. Plasma DOPEG levels (measured at 8 a.m.) were found to be similar in dexamethasone suppressor and nonsuppressor depressed patients. These results do not support the hypothesis that central noradrenergic hypoactivity underlies nonsuppression of dexamethasone in major depression.
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C Benkelfat, and
M F Poirier, and
C Gay, and
S Askienazy, and
T Dennis, and
B Scatton
January 1985,
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H Lôo, and
C Benkelfat, and
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December 1984,
Psychiatry research,
H Lôo, and
C Benkelfat, and
M F Poirier, and
C Gay, and
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January 1986,
Psychopharmacology,
H Lôo, and
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B Scatton
August 1981,
Life sciences,
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M F Poirier, and
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B Scatton
December 1986,
Biological psychiatry,
H Lôo, and
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January 1989,
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao,
H Lôo, and
C Benkelfat, and
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B Scatton
April 1971,
Archives of general psychiatry,
H Lôo, and
C Benkelfat, and
M F Poirier, and
C Gay, and
S Askienazy, and
T Dennis, and
B Scatton
January 1984,
The American journal of psychiatry,
H Lôo, and
C Benkelfat, and
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B Scatton
April 1983,
The American journal of psychiatry,
H Lôo, and
C Benkelfat, and
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B Scatton
January 1988,
Journal of affective disorders,
