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Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release. 2023
Manoj B Sharma, and
Özlem Kap, and
Hend A M Abdelmohsen, and
Mark D Ashton, and
Garry R Harper, and
Melike Firlak, and
Jasmine E Aaltonen, and
Kerry A Bolland, and
Ryan Bragg, and
Sarah Deeley, and
Ella Francis, and
Nahin Kazi, and
Bethany L Mapley, and
Vasileios Oikonomou, and
Amal D Aljohani, and
David Cheneler, and
Volkan Kilic, and
Nesrin Horzum, and
John G Hardy
Department of Chemistry Lancaster University Lancaster LA1 4YB UK.
The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be ≈40 N). Swelling experiments conducted at 20, 35, and 60 °C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.
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