BIOMAT Database Logo BIOMAT Database Logo

Value of Combined Bone Morphogenetic Protein-2/7 Testing in the Assessment of Infected Preterm Labor. 2023

Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen

To analyze the clinical significance of bone morphogenetic protein-2 (BMP-2) and bone morphogenetic protein-7 (BMP-7), members of the bone morphogenetic protein family, in infectious preterm birth, to provide references for future prevention and management of IPB. The study participants were 20 pregnant women with IPB admitted to between January 2022 and January 2023 (research group) and 20 concurrent normal pregnancies (control group). Serum BMP2, BMP-7 inflammatory factors were quantified. Differences in BMP2 and BMP-7 were identified. The Receiver Operating Characteristic curve analyzed the evaluation value of BMP2 and BMP-7 on infectious preterm birth and adverse pregnancy outcomes in pregnant women, and Pearson correlation coefficient determined the correlation of the two with inflammatory factors levels. The research group was higher in serum BMP2 and BMP-7 levels than control group (P < .05). The joint detection by BMP2 and BMP-7 had a sensitivity of 80.00% and a specificity of 90.00% in diagnosing infectious preterm birth (P < .05), and its sensitivity and specificity in predicting adverse pregnancy outcomes in infectious preterm birth pregnant women were 100.0% and 66.67%, respectively (P < .05). According to Pearson correlation coefficient analysis, there was an obvious positive relationship between BMP-2 and BMP-7 and inflammatory factors in research group (P < .05). BMP-2 and BMP-7 are elevated in IPB and are linked to inflammatory factor levels. Joint detection of BMP2 and BMP-7 shows promising potential for evaluating infectious preterm birth.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007752 Obstetric Labor, Premature Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime during the 29th through 38th week of PREGNANCY. TOCOLYSIS inhibits premature labor and can prevent the BIRTH of premature infants (INFANT, PREMATURE). Preterm Labor,Labor, Premature,Premature Labor,Premature Obstetric Labor,Labor, Premature Obstetric,Labor, Preterm
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D047928 Premature Birth CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION). Preterm Birth,Birth, Premature,Birth, Preterm,Births, Premature,Births, Preterm,Premature Births,Preterm Births
D055419 Bone Morphogenetic Protein 7 A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis. BMP-7,Osteogenic Protein-1,Osteogenic Protein 1
D019485 Bone Morphogenetic Proteins Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. Bone Morphogenetic Protein,Morphogenetic Protein, Bone,Morphogenetic Proteins, Bone

Related Publications

Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Expression of bone morphogenetic protein 2 in normal spontaneous labor at term, preterm labor, and preterm premature rupture of membranes.
September 2005, American journal of obstetrics and gynecology,
Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Mechanical testing of recombinant human bone morphogenetic protein-7 regenerated bone in sheep mandibles.
January 2004, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine,
Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Genetic analyses of bone morphogenetic protein 2, 4 and 7 in congenital combined pituitary hormone deficiency.
December 2013, BMC endocrine disorders,
Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Assay of bone morphogenetic protein-2, -4, and -7 in human demineralized bone matrix.
January 2006, The Journal of craniofacial surgery,
Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Periodontally accelerated osteogenic orthodontics combined with recombinant human bone morphogenetic protein-2: An outcome assessment.
January 2019, Journal of Indian Society of Periodontology,
Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Bone morphogenetic protein 7 (BMP-7) influences tendon-bone integration in vitro.
January 2015, PloS one,
Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Bone morphogenetic protein-2, but not bone morphogenetic protein-7, promotes dendritic growth and calbindin phenotype in cultured rat striatal neurons.
January 2001, Neuroscience,
Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Bone morphogenetic protein-binding peptide reduces the inflammatory response to recombinant human bone morphogenetic protein-2 and recombinant human bone morphogenetic protein-7 in a rodent model of soft-tissue inflammation.
June 2011, The spine journal : official journal of the North American Spine Society,
Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Bone morphogenetic protein-7 expression in human pyelonephritis.
April 2010, Collegium antropologicum,
Jinlai Zhan, and Nan Huang, and Wenbin Zhao, and Lin Qiu, and Yin Zhu, and Jieyu Chen, and Xiangjun Chen
Expression of bone morphogenetic protein-7 (BMP-7) in human prostate.
April 2004, The Prostate,
Copied contents to your clipboard!