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The effect of taftsine (T) tetrapeptide was studied on the systemic and subcellular levels. T was found to exert a specific effect on the activities of acetylcholinesterase and MAO molecular forms. The use of T altered the evoked potentials to a signal light stimulus in the cortical and subcortical brain structures. Rearrangements of the membranous proteins (by the content of sulfhydryl groups) detected in subfractions of synaptosomes were most expressed in the visual zone of the cortex. Thus, T exerts a modifying influence on various aspects of mediator metabolism and also on the perception of biologically important sensory stimuli.
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