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Pretreatment of Lewis rats with a series of injections of a renal tubular antigen (RTA) in IFA prevented induction of Heymann's nephritis (HN) when the rats were challenged with RTA in FCA. This absence of disease was confirmed by immunofluorescent staining for rat IgG and histologic examination of the kidneys as well as by lack of development of significant proteinuria. Passive transfer of spleen and lymph node cells from rats receiving such pretreatment into syngeneic recipients prevented induction of HN when these recipients were challenged with RTA in FCA. Passive transfer of serum obtained from pretreated rats was without effect. These results suggest that one of the mechanisms involved in preventing HN by this pretreatment regimen was the induction of suppressor cells. The results of spleen cell transformation indicated that the suppressor cells were specific for RTA as the immune response to a second antigen, PPD, was unaffected. When rats already had active early HN, the diseas course was unaffected by transfer of suppressor cells.
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
March 1986,
Cellular immunology,
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
December 1984,
Clinical immunology and immunopathology,
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
January 1984,
Annual review of immunology,
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
October 1989,
British journal of experimental pathology,
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
August 1987,
Kidney international,
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
April 1976,
European journal of immunology,
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
June 1978,
Transplantation proceedings,
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
August 1984,
British journal of experimental pathology,
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
October 1977,
Journal of immunology (Baltimore, Md. : 1950),
A Litwin, and
J A Bash, and
L E Adams, and
R J Donovan, and
E V Hess
April 1991,
Cellular immunology,
