Biomaterial Database

Effects of neurotensin in feline pial arteries, guinea-pig ileum and portal vein of rat and guinea-pig. 1986

F Wagner, and M Wahl

The effect of neurotensin (NT) was investigated in several vascular and intestinal smooth muscle preparations. No effect of NT (6 X 10(-12)-6 X 10(-5) M) was detected in feline pial arteries in situ employing perivascular microapplication and TV-image splitting for the measurement of vascular diameter. In vitro, the effect of NT was derived from recordings of isometric contraction. NT (10(-10)-10(-5) M) did not influence basal tension, frequency and peak phasic contraction of the whole guinea-pig portal vein (GPV) or its longitudinal strip (GLSPV). Intact reactivity of these preparations was derived from the contraction induced by carbamoylcholine or norepinephrine. In contrast, NT (6 X 10(-10)-6 X 10(-6) M) increased basal tension, frequency, and peak phasic contraction of the longitudinal strip of rat portal vein (RLSPV). Furthermore, NT induced a dose-dependent contraction in the terminal ileum of the guinea-pig (GTI) which was preceded by a transient relaxation. Comparing the effects obtained in GPV and GTI or found in RLSPV and GLSPV it is evident that the variable effects of NT depend on the location of smooth muscle and on animal species, respectively.

UI	MeSH Term	Description	Entries
D007082	Ileum	The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D008297	Male		Males
D009119	Muscle Contraction	A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009130	Muscle, Smooth	Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)	Muscle, Involuntary,Smooth Muscle,Involuntary Muscle,Involuntary Muscles,Muscles, Involuntary,Muscles, Smooth,Smooth Muscles
D009131	Muscle, Smooth, Vascular	The nonstriated involuntary muscle tissue of blood vessels.	Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D009496	Neurotensin	A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.
D011169	Portal Vein	A short thick vein formed by union of the superior mesenteric vein and the splenic vein.	Portal Veins,Vein, Portal,Veins, Portal
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002536	Cerebral Arteries	The arterial blood vessels supplying the CEREBRUM.	Arteries, Cerebral,Artery, Cerebral,Cerebral Artery
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea