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Although 60% of Stage I renal carcinoma patients die from tumor within 5 years postoperatively, a considerable percentage survive that period. Nuclear grading can help to predict the outcome, but many of the patients are Grade 2, and the prognosis of this subclass is uncertain. Therefore, nuclear morphometry was carried out in 41 patients with Stage I renal cell carcinoma. Of these, 24 died within 5 years and 17 have survived that period. Using a mean nuclear area of 32 micron 2 as the decision threshold, none of the 24 short-term survivors are below that threshold and three of the long-term survivors exceed that value (18% false-positives) (99% confidence limit). Separate analysis with sets for learning and testing and Grade 2 patients gave similar results. The results show the essential prognostic value of morphometry in this set of patients with Stage I renal cell carcinoma.
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
January 1999,
Histology and histopathology,
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
January 1995,
European urology,
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
July 2002,
BJU international,
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
January 1999,
Urology,
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
January 1998,
Anticancer research,
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
January 1994,
Investigative urology (Berlin, Germany),
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
July 1999,
Laboratory investigation; a journal of technical methods and pathology,
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
November 1989,
Urology,
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
October 1994,
Pathology,
P Tosi, and
P Luzi, and
J P Baak, and
C Miracco, and
R Santopietro, and
C Vindigni, and
F M Mattei, and
A Acconcia, and
M R Massai
August 1993,
Zentralblatt fur Pathologie,
