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This study was undertaken to examine the possible relationships between muscle capillary basement membrane width (CBMW) and glycemic control, bone age, chronologic age, and duration of diabetes in young patients with insulin-dependent diabetes mellitus (IDDM) during different stages of pubertal development. We studied 49 males and 43 females (age, 7-20 yr) with IDDM for up to 16 yr for whom bone age and glycosylated hemoglobin (HbA1c) data were available at the time of right quadriceps muscle biopsy. Based on pubic hair Tanner stage, subjects were assigned to prepubertal (Tanner I), pubertal (Tanner II and III), and postpubertal (Tanner IV and V) groups. In 30 pubertal and prepubertal subjects, none of the variables studied was significantly correlated with CBMW. This is attributable in part to the small number of subjects in each group. In 62 postpubertal subjects, CBMW was correlated with age (r = .27, P = .03), bone age (r = .43, P = .0005), and postpubertal duration of diabetes (r = .38, P = .003) but not total duration of diabetes. In the postpubertal subjects, CBMW was correlated with HbA1c at the time of biopsy (r = .31, P = .01) but correlated more strongly with the mean of HbA1c values obtained during the 1- and 2-yr periods before biopsy (r = .37, P = .01, and r = .54, P = .03, respectively). An analysis of covariance revealed that the slopes for the regression of loge CBMW on HbA1c differed significantly (P = .02) among the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
March 1975,
The American journal of medicine,
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
May 1984,
The New England journal of medicine,
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
January 1966,
Transactions of the Association of American Physicians,
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
February 1979,
The Journal of clinical endocrinology and metabolism,
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
October 1989,
The Journal of clinical endocrinology and metabolism,
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
January 1994,
Clinical therapeutics,
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
July 1986,
The Journal of clinical investigation,
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
December 1983,
The New England journal of medicine,
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
February 1988,
Diabetes research and clinical practice,
D G Rogers, and
N H White, and
J V Santiago, and
J P Miller, and
V V Weldon, and
C Kilo, and
J R Williamson
January 1987,
Diabetes care,
