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Ten cats were stimulated twice a day in the lateral amygdala with low-frequency stimulation of about 3 Hz until generalized convulsion occurred. After the completion of kindling, the longest interpulse interval required for provocation of generalized convulsion (pulse-interval threshold) was determined in each subject. The pulse-interval threshold was 1300 ms in five cats, and 900 ms in five other cats. Then the stability of pulse-interval threshold and of the number of stimulating pulses required for provocation of afterdischarge when the stimulation was delivered with the pulse-interval threshold (pulse-number threshold) was tested. The pulse-interval threshold, pulse-number threshold, and duration of afterdischarge in each stimulation did not change statistically at the interstimulation interval from 24 h to 7 days. Phenobarbital and diphenylhydantoin elevated the pulse-number threshold significantly. We propose that low-frequency kindling is a valuable experimental model of epilepsy in assessing simply and precisely the susceptibility of the epileptic focus itself and the severity of epileptic seizures.
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
January 1978,
Electroencephalography and clinical neurophysiology. Supplement,
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
August 2009,
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques,
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
November 1976,
Psychological bulletin,
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
January 1981,
Neuroscience,
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
December 1994,
Methods and findings in experimental and clinical pharmacology,
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
January 1986,
Advances in neurology,
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
January 1986,
Progress in neurobiology,
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
September 1992,
The Japanese journal of psychiatry and neurology,
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
January 1980,
Progress in neurobiology,
Y Minabe, and
Y Tanii, and
Y Kadono, and
M Tsutsumi, and
I Nakamura
August 2022,
Computers in biology and medicine,
