-transparent.png){kind=logo}
The complete amino acid sequence of Cu,Zn superoxide dismutase from sheep erythrocytes has been determined. The sequence is very similar to that of the bovine enzyme, having the same number of residues (151) and only two substitutions in the 'hypervariable' region (residues 17-30). The 5 overall substitutions confer a positive charge on the sheep enzyme at neutral pH (pI approximately equal to 8). This charge is localized outside the active site region. The catalytic efficiency of the sheep enzyme is 15% less than that of the cow enzyme, confirming the hypothesis that the enzyme activity is related to the concentration of positive surface charge near the active site channel.
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
January 2016,
Frontiers in physiology,
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
June 1983,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
April 1985,
Biological chemistry Hoppe-Seyler,
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
August 2006,
The journal of physical chemistry. B,
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
June 1986,
Proceedings of the National Academy of Sciences of the United States of America,
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
January 1990,
Clinica chimica acta; international journal of clinical chemistry,
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
December 1991,
Acta crystallographica. Section B, Structural science,
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
December 1992,
Archives of biochemistry and biophysics,
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
June 1995,
Plant physiology,
M E Schininà, and
D Barra, and
S Gentilomo, and
F Bossa, and
C Capo, and
G Rotilio, and
L Calabrese
September 2004,
Acta crystallographica. Section D, Biological crystallography,
